Magnevist® (gadopentetate dimeglumine) injection
Central Nervous System: Magnevist® (gadopentetate dimeglumine) injection is indicated for the use with magnetic resonance imaging (MRI) in adults and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues. Magnevist® has been shown to facilitate visualization of intracranial lesions including but not limited to tumors.
Extracranial/Extraspinal Tissues: Magnevist® is indicated for use with MRI in adults and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the head and neck.
Body: Magnevist® is indicated for use with MRI in adults and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the body.
Magnevist® is contraindicated in patients with:
- Chronic, severe kidney disease (glomerular filtration rate, GFR <30 mL/min/1.73m2), or
- Acute kidney injury, or
- History of severe hypersensitivity reactions to Magnevist®
Anaphylactoid and anaphylactic reactions with cardiovascular, respiratory and/or cutaneous manifestations rarely resulting in death have occurred. The risk of hypersensitivity reactions is higher in patients with a history of reaction to contrast media, bronchial asthma, or allergic disorders. Hypersensitivity reactions can occur with or without prior exposure to GBCAs.
Safety profile in pivotal clinical trials1
‡Occurring in ≥1% of patients.
- In US clinical trials of 1272 patients, the most frequently reported adverse reactions included headache, nausea, and injection-site coldness/localized coldness
- Clinical trials have demonstrated efficacy and safety of Magnevist® at the approved dose of 0.1 mmol/kg across all indications
- Serious or life-threatening anaphylactic or anaphylactoid reactions, including cardiovascular, respiratory, and/or cutaneous manifestations, should always be considered
Please see Full Prescribing Information, including boxed warning.
References: 1. Magnevist Injection [package insert]. Whippany, NJ: Bayer HealthCare Pharmaceuticals Inc.; 2014.Back to top
Magnevist® (gadopentetate dimeglumine) injection is an MRI-contrast agent with a 24-hour time of use for both 50-mL and 100-mL multi-dose Pharmacy Bulk Packages.
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The Bayer Imaging Reimbursement Helpline is available to all institutions to provide further information. The Helpline can be reached by phone (1-800-423-7539).Back to top
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